Journal of Medicinal and Pharmaceutical Chemistry Research

Demographic trends in COVID-19 prevalence at a primary hospital of Mashhad: a screening study

Shadi Saghafi Khadem; Zohre Arzaghi; Behrang Rezvani Kakhki; Maryam Ziyaei; Fatemeh Maleki; Ehsan Bolvardi; Mahdi Foroughian

Volume 6, Issue 7 , July 2024, , Pages 842-854

https://doi.org/10.48309/jmpcr.2024.436430.1095

Abstract

This study intricately explores the demographic dynamics influence on infection rates, disease severity, and mortality attributed to the virus. Through a meticulous examination of these ... Read More

Serum troponin level relationship with prognosis of nontraumatic cerebral hemorrhage

Yeganeh Youzbashizadeh; Morteza Saeedi; Zahra Abbasi Shayeh; Ehsan Bolvardi; Maryam Sobhani; Mahdi Foroughian; Maryam Ziyaei; Fatemeh Maleki; Amir Masoud Hashemian

Volume 6, Issue 4 , April 2024, , Pages 447-455

https://doi.org/10.48309/jmpcr.2024.430139.1057

Abstract

Background and aim: Assessment of the prognosis of the intracranial hemorrhage (ICH) is important in case of patients’ follow up and management. It is reported that there might ... Read More Background and aim: Assessment of the prognosis of the intracranial hemorrhage (ICH) is important in case of patients’ follow up and management. It is reported that there might be some links between serum troponin levels (TPI) and ICH. However, there is a gap of knowledge in case of nontraumatic cases. The aim of this study was to investigate the relationship between TPI and prognosis of patients with non-traumatic cerebral hemorrhage.Method: This retrospective cohort study was conducted on all non-traumatic stroke patients referred to the emergency room of Ghaem Hospital (AJ) on patients with confirmed ICH in CT scan. Patients were included in the study after obtaining consent from them or their legal guardians. Brain CT scan was used to determine the location and volume of bleeding, midline changes, and presence of intraventricular hemorrhage (IVH). The bleeding volume was estimated using the formula (ABC)/2. The primary troponin (cTnT) test was performed within 12 hours of the onset of symptoms for each patient. A serum cTnT value ≥0.01 ng/ml was set as the cut-off value, and then the patients were divided into two groups: normal troponin and increased troponin level, and also their prognosis was determined based on the ICH Score and Predicting Mortality after Acute ICH table. Next, after 3 days, all patients in both groups were contacted and their disease status was determined based on the Modified Ranking Scale. The collected data were subjected to statistical analysis by SPSS.Results: A total of 387 patients were included in our study, including 214 men (55.3%) and 173 (44.7%) women. The average age of the patients was 66.16 years and ranged from 19 to 95 years. 81 patients (20.9%) had increased troponin based on the determined level. In addition, 174 patients (45.0%) died during hospitalization. The mean of ICH Score was 2.37 ± 0.99 and the mean of Modified Ranking Scale was 3.24 ± 2.49. There was no significant difference in terms of troponin level (p=0.250) and gender (p=0.508) between those who died and those who were discharged with partial recovery.Conclusion: There was no significant relationship between troponin and the outcome of non-traumatic brain hemorrhage patients, but after adjustments, the troponin levels were increased. However, it seems that the level of 0.01 ng investigated in our study is not suitable, and it is possible that other levels will provide better results.

Systematic review and meta-analysis of narcolepsy management during the covid-19 pandemic

Mansour Deylami; Majid Vatankhah; Tayyebeh Zarei; Ehsan Rahmanian; Farshid Javdani; Shahram Shafa; Hasan Zabetian; Minou Najar Nobari; Kaveh Hedayati Emami; Fatemeh Maleki; Amin Shafiei; Vida Hafezi; Roohie Farzaneh; Mohammad Sadegh Sanie Jahromi

Volume 6, Issue 3 , March 2024, , Pages 292-301

https://doi.org/10.48309/jmpcr.2024.424911.1034

Abstract

The concern has recently been raised for disease status and management of people with narcolepsy after initiation of COVID-19 pandemic. Here, we evaluated the literature to determine ... Read More

Prognostic value of lymphocytes counts, serum CRP levels, and lung CT scan findings and the final disease outcome in COVID-19

Zohreh Azarkar; Ali Mohammad Zadeh; Roohie Farzaneh; Mahdi Foroughian; Behrang Rezvani Kakhki; Maryam Sobhani; Molood Fogerdi; Maryam Ziyaei; Fatemeh Maleki

Volume 6, Issue 3 , March 2024, , Pages 334-343

https://doi.org/10.48309/jmpcr.2024.425556.1036

Abstract

Introduction: Understanding the interplay of paraclinical factors in individuals with COVID-19 is crucial for predicting disease prognosis. This study aims to explore the correlation ... Read More Introduction: Understanding the interplay of paraclinical factors in individuals with COVID-19 is crucial for predicting disease prognosis. This study aims to explore the correlation between lymphocyte count, C-reactive protein (CRP) serum levels, CT scan findings, and the ultimate outcome in patients with COVID-19 pneumonia at Valiasr Hospital in Birjand.Methods: Conducting a retrospective analysis, this study investigated 258 COVID-19 patients aged 14 and above, who sought medical attention at Valiasr Hospital in Birjand city in 2020. The research meticulously documented patients' demographic details encompassing gender, age, education level, underlying health conditions, lymphocyte count, and other pertinent information. CT scan findings, the ultimate patient outcomes, and serum levels of CRP were systematically recorded and comprehensively analyzed using a study checklist. This comprehensive examination aims to provide a detailed retrospective understanding of the multifaceted factors influencing COVID-19 outcomes among patients in Birjand.Findings: The average age was 61.06±20.06 years. 50.8% of patients were male. 10.9% of patients died. The average number of lymphocytes did not differ significantly according to the severity of lung involvement (P=0.291), but the average number of WBC (P=0.031), the percentage of lymphocytes (P=0.047) and CRP (P<0.001) was significantly different from each other according to the severity of the conflict. CRP levels in discharged group were significantly lower than dead, ward and ICU admitted ones (P<0.05). CRP levels were significantly lower in without lung involvement patients than all other groups except the mild involvement group (P<0.05).Conclusion: Elevated serum levels of CRP and white blood cell count, coupled with a decrease in lymphocyte percentage, were linked to more lung involvement. Furthermore, a reduction in both the number and percentage of lymphocytes correlated with a more severe condition as well as the high CRP levels’ effect.

Investigating the difference of negative pressure in tracheal and esophageal intubation immediately after the end of cardiopulmonary resuscitation in patients referred to the emergency room

Arman Hakemi; Sahar Nosrati; Seyed Reza Habibzadeh; Majid Khadem Rezaiyan; Maryam Ziyaei; Roohie Farzaneh; Fatemeh Maleki; Mahdi Foroughian

Volume 6, Issue 1 , January 2024, , Pages 82-88

https://doi.org/10.48309/jmpcr.2024.421384.1022

Abstract

This study aimed to determine and compare the negative pressure in tracheal and esophageal intubation in the corpses immediately after the end of cardiopulmonary resuscitation. The ... Read More

Journal of Medicinal and Pharmaceutical Chemistry Research

Articles in Press

Current Issue

Volume 6 (2024)

Volume 5 (2023)

Volume 4 (2022)

Volume 3 (2021)

Volume 2 (2020)

Volume 1 (2019)

Author = Maleki, Fatemeh

Demographic trends in COVID-19 prevalence at a primary hospital of Mashhad: a screening study

Abstract

Serum troponin level relationship with prognosis of nontraumatic cerebral hemorrhage

Abstract

Systematic review and meta-analysis of narcolepsy management during the covid-19 pandemic

Abstract

Prognostic value of lymphocytes counts, serum CRP levels, and lung CT scan findings and the final disease outcome in COVID-19

Abstract

Investigating the difference of negative pressure in tracheal and esophageal intubation immediately after the end of cardiopulmonary resuscitation in patients referred to the emergency room

Abstract